1o0d
Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
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OverviewOverview
Synthesis of thrombin inhibitors and their binding mode to thrombin is, described. Modification of the P1 moiety leads to an increased selectivity, versus trypsin. The observed selectivity is discussed in view of their, thrombin-inhibitor complex X-ray structures.
DiseaseDisease
Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this StructureAbout this Structure
1O0D is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
ReferenceReference
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189
Page seeded by OCA on Fri Feb 15 16:31:44 2008