Sandbox SouthUniversity3

==Integrase as an anti-HIV drug target==

The structure to the left shows a molecule of the integrase enzyme caught in the act as it incorporates viral DNA into human DNA. Turn spinning off by pressing the "toggle spin" button below the molecule. You may also press "toggle quality", although this may slow the animation, depending on your computer.You can rotate the molecule by clicking and dragging horizontally,or by using your scroll wheel. It can be re-sized by dragging horizontally. Viral DNA is highlighted here as a One strand of human DNA can be seen here The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown displayed in a space filling representation.It is easier to see the functional groups displayed as Note the 3 oxygen atoms labeled . They are a vital part of the structure, since they bind (chelate) to 2 magnesium ions within the enzyme.

spinqualitylabelsall models Structure of integrase in action (PDB entry 3os1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image