1ga3
NMR STRUCTURE OF INTERLEUKIN-13
|
OverviewOverview
The complex and interrelated function of the interleukin cytokines relies, on a range of pro-inflammatory and anti-inflammatory immune responses, mediated by an array of receptors, and there is considerable, cross-reactivity for related cytokines. Recent findings continue to, elucidate the expression patterns of interleukin receptors associated with, a range of diseases, including cancer. We report here the first, experimentally determined high-resolution structure of human, interleukin-13 (IL-13). The experimental structure is significantly, different from an earlier homology model, which could have led to improper, estimation of receptor interaction surfaces and design of mutational, experiments. Similarities between the presented IL-13 structure and the, homologous interleukin-4 (IL-4) are discussed. Additionally, mutation data, for IL-4 and IL-13 are analyzed and combined with a detailed structural, analysis of the IL-4/IL4Ralpha interface that leads us to postulate, interactions at the IL-13/receptor interface. The structural comparison is, used to interpret the different affinities for various receptors and, establishes the basis for further mutational experiments and antagonist, design.
DiseaseDisease
Known diseases associated with this structure: Allergic rhinitis, susceptibility to OMIM:[147683], Asthma, susceptibility to OMIM:[147683]
About this StructureAbout this Structure
1GA3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of interleukin-13 and insights into receptor engagement., Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA, J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:11419949
Page seeded by OCA on Fri Feb 15 15:51:53 2008