Nucleoside diphosphate kinase
Nucleoside diphosphate kinase (NDK) catalyzes the transfer of phosphate from nucleoside triphosphate to nucleoside diphosphate. This reaction is a multi-step reaction and is used for the synthesis of nucleoside triphosphates other than ATP. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polimerization.
3D structures of nucleoside diphosphate kinase3D structures of nucleoside diphosphate kinase
1ndk, 1npk, 1s5z – DdNDK – Dictyostelium discoideum
1nlk - DdNDK with phosphohistidine intermediate
1leo, 1ncl, 1hlw, 1hhq, 1pae - DdNDK (mutant)
2nck – MxNDK – Myxococcus xanthus
1ndl – DmNDK – Drosophila melanogaster
1nsq - DmNDK with phosphohistidine intermediate
1nsk, 1jxv, 3l7u - hNDK A – human
1ehw - hNDK 4 (mutant)
1k44 – NDK – Mycobacterium tuberculosis
1nb2 - NDK - Virgibacillus halodenitrificans
1xiq - NDK A – Plasmodium falciparum
1w7w - NDK – pea
1u8w - AtNDK I – Arabidopsis thaliana
1s57 - AtNDK II
1pku - NDK I – rice
1wkj - TtNDK – Thermus thermophilus
1xqi - NDK (mutant) – Pyrobaculum aerophilum
2az1 - HsNDK – Halobacterium salinarum
2hur - NDK – Escherichia coli
3b54 - NDK – yeast
2vu5 - NDK – Bacillus anthracis
2zua - NDK – Haloarcula quadrata
3mpd - NDK – Encephalitozoon cuniculi
3pj9 - NDK – Campylobacter jejuni
3r9l - NDK – Giardia lamblia
3ngr, 3ngs - LmNDK – Leishmania major
3prv - NDK – Trypanosoma cruzi
3q83 - SaNDK – Staphylococcus aureus
4di6 - BbNDK – Borrelia burgdorferi
3ztq, 3zto, 3ztp, 3ztr, 3zts - NDK – Aquifex aeolicus
4dut - NDK – Burkholderia thailandensis
NDK complex with adenine derivative
1ndp, kdn, 2bef – DdNDK + ADP
1b4s - DdNDK (mutant) + ADP
1bux, 1hiy - DdNDK + ADP derivative
1nlk - MxNDK + ADP
2hvd - hNDK + ADP
1ucn, 2hve - hNDK (mutant) + ADP
1zs6 - hNDK 3 + ADP
2dxd - PhNDK + ATP analog – Pyrococcus horikoshii
2dy9, 2dya - PhNDK + ADP
3ngt - LmNDK + AMP
3ngu - LmNDK + ADP
3q8u, 3q8y - SaNDK + ADP
4dz6 - BbNDK + ADP
NDK complex with thymidine derivative
1f3f - DdNDK (mutant) + TDP derivative + TTP derivative
1lwx - DdNDK (mutant) + azido-TDP
1f6t - DdNDK + TDP derivative
1mn7 - DdNDK (mutant) + TTP derivative
1ndc - DdNDK + TDP
3ddi - ApNDK (mutant) + TDP – Acanthamoeba polyphaga
3em1, 3evw, 3fbc, 3fbf, 3g2x, 3evo - ApNDK (mutant) + TDP derivative
NDK complex with cytosine derivative
1nhk - MxNDK + CMP
2az3 - HsNDK + CDP
3ee3 - ApNDK + CDP
3etm, 3gpa, 3fc9 - ApNDK (mutant) + CDP
3evm - ApNDK (mutant) + CDP derivative
3q89 - SaNDK + CDP
NDK complex with guanine derivative
1nue , 3bbf - hNDK + GDP
1s59 - AtNDK + GDP derivative + GTP derivative
3bbb - hNDK B + GMP derivative + AMP derivative
1wkk - TtNDK + GDP
2dxe - PhNDK + GDP
2dxf - PhNDK + GTP analog
3gp9 - ApNDK + GDP
3b6b - ApNDK + GDP derivative
3fbe, 3dkd, 3ejm - ApNDK (mutant) + GDP
3emt, 3ena - ApNDK (mutant) + GDP derivative
3q86 - SaNDK + GTP
NDK complex with uridine derivative
1b99 - DdNDK + UDP derivative
3eic - ApNDK + UDP
3elh - ApNDK + UDP derivative
3fbb, 3fcv - ApNDK (mutant) + UDP derivative
3fcw - ApNDK (mutant) + UDP
3q8v - SaNDK + UDP