Interleukin-1 receptor-associated kinase

Template:STRUCTURE 2oid

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins. IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection. IRAK4 deficiency is a disorder which causes recurrent bacterial infections.

3D structures of IRAK43D structures of IRAK4

2nru, 2nry, 2oib, 2o8y – hIRAK4 kinase domain - human
1wh4 – mIRAK4 DEATH domain – mouse – NMR
2a9i - mIRAK4 DEATH domain
2oic - hIRAK4 kinase domain + staurosporine
2oid - hIRAK4 kinase domain + AMPPNP
3mop - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88

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