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Protussis Toxins"" is a major virulence factor of 'Bordetella pertussis' that cause whooping cough. Whooping cough, also known as pertusis, is a highly contagious bacterial disease caused by Bordetella pertussis. This disease had been characterized by severe cough that has been documented to cause subconjunctival hemorrhages, rib fractures, hernias, fainting and vertebral artery dissection. The pertussis toxin has been characterized as being a AB toxin meaning that there are 2 subunits: A subunit possesses the enzyme activity and the B subunit it the receptor binding portion. Together this AB toxin colonizes the respiratory tract and becomes activated by destabilization due to the binding of ATP
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