Ficolin

Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.

3D Structures of Ficoln3D Structures of Ficoln

H-ficolinH-ficolin

2j64 - hH-Fic binding domain - human
2j5z - hH-Fic binding domain + galactose
2j60 - hH-Fic binding domain + fucose
2j61 - hH-Fic binding domain + acetyl-glucosamine

L-ficolinL-ficolin

2j3g - hL-Fic binding domain
2j0g – hL-Fic binding domain + N-acetyl-mannosamine
2j0h - hL-Fic binding domain + acetylcholine
2j0y - hL-Fic binding domain + glucan
2j1g, 2j2p - hL-Fic binding domain + acetylcysteine
2j3f - hL-Fic binding domain + galactosamine
2j3o - hL-Fic binding domain + acetyl-glucosamine
2j3u - hL-Fic binding domain + galactose

M-ficolinM-ficolin

2d39 – hM-Fic fibrinogen-like domain
2wnp - hM-Fic fibrinogen-like domain (mutant)
2jhh, 2jhm – hM-Fic C terminal
2jhi - hL-Mic C terminal + acetyl-galactosamine
2jhk - hL-Mic C terminal + acetyl-glucosamine
2jhl - hL-Mic C terminal + sialic acid