365d
|
STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE
OverviewOverview
Small molecules that target specific DNA sequences offer a potentially, general approach for the regulation of gene expression. Pyrrole-imidazole, polyamides represent the only class of synthetic small molecules that can, bind predetermined DNA sequences with affinities and specificities, comparable to DNA binding proteins. Antiparallel side-by-side pairings of, two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C, from C.G, and both from A.T/T.A base pairs. A high resolution X-ray, crystal structure of a four-ring pyrrole-imidazole polyamide specifically, bound as a dimer to a six-base pair predetermined DNA site reveals a, structural framework of hydrogen bonds and interactions with the walls of, the minor groove that underlies the pairing rules for DNA recognition.
About this StructureAbout this Structure
365D is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074
Page seeded by OCA on Tue Jan 29 21:36:46 2008