Peroxiredoxin
Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. The images at the left and at the right correspond to one representative Prx, i.e. the crystal structure of Peroxiredoxin from rat (1qq2).
3D Structures of Peroxiredoxin3D Structures of Peroxiredoxin
1qq2 – 2Cys-Prx – rat
2c0d – Pf2Cys-Prx – Plasmodium falciparum
1xiy – Pf1Cys-Prx
1xcc, 2h01 - 1Cys-Prx – Plasmodium yoelii
2i81 - 2Cys-Prx – Plasmodium vivax
1qmv - h2Cys-Prx – human
2rii, 3hy2 – hPrx 1 (mutant)+sulfiredoxin 1
2z9s – Prx 1 (mutant) - rat
2pn8 – hPrx 4
1urm – hPrx 5 (mutant) – human
2vl2, 2vl3, 2vl9, 1h4o, 1hd2, 1oc3 – hPrx 5
3mng – hPrx 5+DTT
2wfc – lPrx 5 - lugworm
2v2g – lPrx 6
2v32, 2v41 – lPrx 6 (mutant)
2a4v – yPrx dot5 C-termianl (mutant) – yeast
3cmi – yPrx hyr1
1tp9 – Prx II – Populus trichocarpa
2pwj – Prx II – garden pea
1uul - 2Cys-Prx – Trypanosoma cruzi
1we0 – Prx – Amphibacillus xylanus
1zye – Prx III (mutant) – bovine
2cv4, 2cx3, 2cx4 – Prx – Aeropyrum pernix
3drn – SsPrx – Sulfolobus solfataricus
3hjp – SsPrx (mutant)
3ixr – Prx PRXQ (mutant) – Xylella fastidiosa