Ribonucleotide reductase
Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. The RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Thymidine triphosphate (TTP) is an effector in the reaction.
3D Structures of Ribonucletide reductase3D Structures of Ribonucletide reductase
RNR large subunitRNR large subunit
1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
1pem - StRNR R1 - Salmonella typhimurium
5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli
RNR large subunit complexRNR large subunit complex
3hnc – hRNR M1 + TTP – human
3hnd – hRNR M1 + GDP + TTP
3hne, [[3hnf – hRNR M1 + ATP + TTP
2wgh - hRNR M1 + ATP + Mg
3paw - yRNR R1 + ATP
3k8t - yRNR R1 + ADP analog
2zlf, 2zlg - yRNR R1 + peptide
2eud - yRNR R1 + ligand
1peo, 1peq, 2peu - StRNR R1 + effector
2r1r - EcRNR R1 + TTP
3r1r - EcRNR R1 + AMPPNP
4r1r - EcRNR R1 + GDP + TTP
RNR small subunitRNR small subunit
2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib – EcRNR R2
1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
3hf1, 2vux, 2uw2 – hRNR M2
3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
2p1i – RNR R2 – Plasmodium yoelii
2o1z - RNR R2 – Plasmodium vivax
1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
1smq, 1sms – yRNR 2
1syy - CtRNR R2 – Chlamydia trachomatis
2ani - CtRNR R2 (mutant)
1uzr – RNR R2 – Mycobacterium tuberculosis
1r2f - StRNR R2
RNR small subunit complexRNR small subunit complex
1rsr, 1rsv - EcRNR R2 (mutant) + N3
3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
1rnr – EcRNR R2 (mutant) + dopa
1w69 – mRNR R2 + acetate
RNR small+large subunitRNR small+large subunit
2xo4, 2xo5 - EcRNR R1+ R2
2xak, 2xap - EcRNR R1+ R2 peptide
2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
2bq1 - StRNR R1+ R2
1xjf – TmRNR + ATP – Thermotoga maritima
1xjg - TmRNR + ATP-UDP
1xjj - TmRNR + GTP
1xjk - TmRNR + GTP-ADP
1xjm - TmRNR + TTP
1xje - TmRNR + TTP-GDP
1xjn - TmRNR + ATP-CDP