Group:MUZIC:XIN
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms.
Sequence AnnotationSequence Annotation
Interactions with other proteins/ FunctionInteractions with other proteins/ Function
Xin and Mena/VASP colocalize with filamin c in intercalated discs (ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart [1].
Xin directly binds the EVH1 domain proteins Mena and VASP [2] Xin binds the unique insertion of filamin c containing Ig domain 20.
Xin directly binds F-actin [3]
ReferencesReferences
- ↑ Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009 Dec 15;18(24):4791-800. Epub 2009 Sep 22. PMID:19773341 doi:10.1093/hmg/ddp442
- ↑ van der Ven PF, Ehler E, Vakeel P, Eulitz S, Schenk JA, Milting H, Micheel B, Furst DO. Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP. Exp Cell Res. 2006 Jul 1;312(11):2154-67. Epub 2006 Apr 24. PMID:16631741 doi:S0014-4827(06)00110-8
- ↑ Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF. Xin repeats define a novel actin-binding motif. J Cell Sci. 2004 Oct 15;117(Pt 22):5257-68. Epub 2004 Sep 28. PMID:15454575 doi:10.1242/jcs.01406