Plectin
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure (1). C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
1. Foisner, R., and Wiche, G. (1987) J Mol Biol 198, 515-531
2. Nikolic, B., Mac Nulty, E., Mir, B., and Wiche, G. (1996) J Cell Biol 134, 1455-1467
3. Fuchs, P., Zorer, M., Rezniczek, G. A., Spazierer, D., Oehler, S., Castanon, M. J., Hauptmann, R., and Wiche, G. (1999) Hum Mol Genet 8, 2461-2472