Neurexin

File:3bod.png

Crystal Structure of mouse β-neurexin 1 3bod

Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. The images at the left and at the right correspond to one representative NRXN, i.e. the crystal structure of mouse β-neurexin 1 (3bod).

For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction

3D Structures of Neurexin3D Structures of Neurexin

Update June 2011

α-NRXNα-NRXN

2h0b - bα-NRXN-1 LNS2 – bovine
2r16 - bα-NRXN-1 LNS 4

β-NRXNβ-NRXN

3mw2 – mβ-NRXN-1 +splice insert 4 – mouse
3bod - mβ-NRXN-1
3bop - mβ-NRXN-2d4
3mw3, 2r1b - rβ-NRXN-2 +splice insert 4 – rat
2r1b - rβ-NRXN-1 +splice insert 4
2r1d - rβ-NRXN-1 +Ca
1c4r - rβ-NRXN-1
3mw4 - mβ-NRXN-3

NRXN+NLGNNRXN+NLGN

2xb6, 2wqz – rβ-NRXN-1 +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain
3biw - rβ-NRXN-1 +rNLGN-1 cholinesterase domain

NRXNNRXN

3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
3bod, 3bop - mNRXN-1α LNS domain
3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
2r16 - rNRXN-1α LNS domain+Ca
1c4r - rNRXN-1α LNS domain
3mw4 - mNRXN-1α LNS domain
2h0b - bNRXN-1α LNS2 domain – bovine
3asi - bNRXN-1α LNS25-EGF3-LNS6 domains

NRXN+NLGNNRXN+NLGN

2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain