Aspartate-semialdehyde dehydrogenase

Crystal Structure of Aspartate-semialdehyde dehydrogenase, 1mc4

Aspartate-semialdehyde dehydrogenase (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, i.e. the crystal structure of Aspartate-semialdehyde dehydrogenase from Vibrio cholerae (1mc4).

3D Structures of Aspartate-semialdehyde dehydrogenase3D Structures of Aspartate-semialdehyde dehydrogenase

2qz9, 1mc4 – VcASADH II – Vibrio cholerae
2yv3 – ASADH – Thermus thermiphilus
1t4d, 1t4b, 1brm - EcASADH β - Escherichia coli
1pu2, 1oza - HiASADH (mutant) – Haemophilus influenzae
1nwc – HiASADH
1nwh – HiASADH reaction intermediate

ASADH binary complexASADH binary complex

2r00 - VcASADH II + ASA
3llg – ASADH + glycerot + Pi – Mycobacterium tuberculosis
3hsk – ASADH + NADP – Candida albicans
1ys4 - ASADH + NADP – Methanocaldococcus jannaschii
1nx6 - HiASADH reaction intermediate +Pi
1ta4 - HiASADH + As
1tb4 - HiASADH + IO4
1q2x - HiASADH (mutant) + ASA

ASADH ternary complexASADH ternary complex

1pqu - HiASADH (mutant) + NADP + cacodylate + substrate analog
1pqp - HiASADH (mutant) + ASA + Pi
1gl3 - EcASADH β + NADP + substrate analog
1mb4 - VcASADH + NADP + substrate analog

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Alexander Berchansky, Michal Harel