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This is the 3FPB Membrane Protein.

Its structure consists of ATP, adenosine 5'-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CZA). A metal (Mg or Mn) must react in the ATP binding site for CZA to bind and react. This occurs at the M1 helix. Knowing the structure of the binding site allows for drugs that can be designed to target this ATPase.

spinqualitylabelsall models PDB ID 3fpb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3fpb, resolution 2.55Å ()
Ligands:	, , , ,
Activity:	Calcium-transporting ATPase, with EC number 3.6.3.8
Related:	2o9j, 3fgo
Structural annotation: Resources: CATH : 3Fpba02, 3Fpba03, 3Fpba04, 3Fpba01 InterPro : Ipr000695, Ipr001757, Ipr004014, Ipr005782, Ipr005834, Ipr006068, Ipr023306, Ipr018303, Ipr023214, Ipr023298, Ipr023299, Ipr023300, Ipr008250 Pfam : PF00122, PF00702, PF00690, PF00689
Evolutionary conservation: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

The following picture shows the M1-M10 helices that are involved sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA). The M1 helix has a kink that is a part of all P-type ATPases. This kink is involved in cytoplasmic cation access pathway. The metal ion needed for binding can also be seen.