Sandbox Reserved 200

This Sandbox is Reserved from Feb 02, 2011, through Jul 31, 2011 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 191 through Sandbox Reserved 200.

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IntroductionIntroduction

File:2D RNase A.png

RNase A minor dimer,1A2W

Bovine pancreatic ribonuclease A (RNase A) is an enzyme that catalyzes the hydrolysis of RNA. RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the monomer. The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit . The 3D domain swapping has no impact on the formation of active sites. These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer .

spinqualitylabelsall models Ribonuclease A Dimer Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

TrimersTrimers

spinqualitylabelsall models Ribonuclease A Minor Trimer Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image