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Human eIF2 (1q8k)Human eIF2 (1q8k)

IntroductionIntroduction

The translation of proteins requires three steps to occur; initiation, elongation and termination. With each step one or more factors is involved in aiding the process. In eukaryotes initiation has the most factors that are essential for initiation to occur. eIF2 is one of the many initiating factors needed for eukaryotic initiation to occur. It is needed for proper initiation to occur. It initially binds to eIF2β with in the presence of GTP. It then binds to Met-tRNA^meti and releases the eIF2β. This specific eIF2(1q8k) is the human eIF2 ^[1].

1q8k, 15 NMR models ()

Gene:

EIF2S1 OR EIF2A (Homo sapiens)

Structural annotation:
Resources:	CATH : 1Q8Ka02, 1Q8Ka01, 1Q8Ka03 InterPro : Ipr011488, Ipr003029, Ipr012340 Pfam : PF00575, PF07541 SCOP : d1q8ka1, d1q8ka2 UniProt : P05198

Functional annotation:
Cellular component:	cytoplasm polysome nucleus eukaryotic translation initiation factor 2 complex eukaryotic translation initiation factor 2B complex
Biological process:	translation regulation of translational initiation in response to stress regulation of translation
Molecular function:	RNA binding protein binding translation initiation factor activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

StructureStructure

The human eIF2 structure was determined by NMR spectroscopy^[2].

FunctionFunction

ReferencesReferences

↑ Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep;12(9):1693-704. PMID:15341733 doi:10.1016/j.str.2004.07.010
↑ Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep;12(9):1693-704. PMID:15341733 doi:10.1016/j.str.2004.07.010

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Steven Kashuba, Andrea Gorrell

[1] Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep;12(9):1693-704. PMID:15341733 doi:10.1016/j.str.2004.07.010

[2] Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep;12(9):1693-704. PMID:15341733 doi:10.1016/j.str.2004.07.010

[1]

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