Sandbox Reserved 313

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

spinqualitylabelsall models PDB ID 2dds Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2dds, resolution 1.80Å ()
Ligands:
Activity:	Sphingomyelin phosphodiesterase, with EC number 3.1.4.12
Related:	2ddr, 2ddt
Structural annotation: Resources: InterPro : Ipr005135 Pfam : PF03372 UniProt : P11889
Functional annotation: Biological process: cytolysis hemolysis by symbiont of host red blood cells Molecular function: sphingomyelin phosphodiesterase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates:	save as pdb, mmCIF, xml

IntroductionIntroduction

Sphingomyelin phosphodiesterase (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine . There are 6 known types of sphingomyelinases:

Acid sphingomyelinase (aSMase) -

Secretory sphingomyelinase (sSMase) -

Neutral, Mg2+-dependent sphingomyelinases (nSMase) -

Mg2+-independent neutral sphingomyelinases -

Alkaline sphingomyelinase -

Bacterial sphingomyelinase -