2jph

Template:STRUCTURE 2jph

File:2jph.png

NMR solution structure of the Rho GTPase binding domain of human plexin-b1NMR solution structure of the Rho GTPase binding domain of human plexin-b1

Template:ABSTRACT PUBMED 18275816

About this StructureAbout this Structure

2jph is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

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↑ Tong Y, Hota PK, Hamaneh MB, Buck M. Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain. Structure. 2008 Feb;16(2):246-58. PMID:18275816 doi:10.1016/j.str.2007.12.012
↑ Tong Y, Hughes D, Placanica L, Buck M. When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteins. Structure. 2005 Jan;13(1):7-15. PMID:15642257 doi:10.1016/j.str.2004.10.018
↑ Tong Y, Buck M. 1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold. J Biomol NMR. 2005 Apr;31(4):369-70. PMID:15929008 doi:10.1007/s10858-005-0943-9
↑ Oinuma I, Ishikawa Y, Katoh H, Negishi M. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science. 2004 Aug 6;305(5685):862-5. PMID:15297673 doi:10.1126/science.1097545
↑ Vikis HG, Li W, He Z, Guan KL. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457-62. PMID:11035813 doi:10.1073/pnas.220421797
↑ Driessens MH, Hu H, Nobes CD, Self A, Jordens I, Goodman CS, Hall A. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Curr Biol. 2001 Mar 6;11(5):339-44. PMID:11267870
↑ Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem. 2007 Dec 21;282(51):37215-24. Epub 2007 Oct 4. PMID:17916560 doi:10.1074/jbc.M703800200

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OCA

[1] Tong Y, Hota PK, Hamaneh MB, Buck M. Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain. Structure. 2008 Feb;16(2):246-58. PMID:18275816 doi:10.1016/j.str.2007.12.012

[2] Tong Y, Hughes D, Placanica L, Buck M. When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteins. Structure. 2005 Jan;13(1):7-15. PMID:15642257 doi:10.1016/j.str.2004.10.018

[3] Tong Y, Buck M. 1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold. J Biomol NMR. 2005 Apr;31(4):369-70. PMID:15929008 doi:10.1007/s10858-005-0943-9

[4] Oinuma I, Ishikawa Y, Katoh H, Negishi M. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science. 2004 Aug 6;305(5685):862-5. PMID:15297673 doi:10.1126/science.1097545

[5] Vikis HG, Li W, He Z, Guan KL. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457-62. PMID:11035813 doi:10.1073/pnas.220421797

[6] Driessens MH, Hu H, Nobes CD, Self A, Jordens I, Goodman CS, Hall A. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Curr Biol. 2001 Mar 6;11(5):339-44. PMID:11267870

[7] Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem. 2007 Dec 21;282(51):37215-24. Epub 2007 Oct 4. PMID:17916560 doi:10.1074/jbc.M703800200

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