2aaz
Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolateCryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate
Template:ABSTRACT PUBMED 16204883
About this StructureAbout this Structure
2aaz is a 16 chain structure with sequence from Filobasidiella neoformans. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. Epub 2005, Sep 28. PMID:16204883 doi:10.1107/S0907444905022638
- ↑ Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P. Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem. 1999 Jun 17;42(12):2112-24. PMID:10377217 doi:10.1021/jm9900016
- ↑ Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:9931028 doi:10.1021/bi9815896