2a4l

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File:2a4l.png

Template:STRUCTURE 2a4l

Human cyclin-dependent kinase 2 in complex with roscovitineHuman cyclin-dependent kinase 2 in complex with roscovitine

Template:ABSTRACT PUBMED 9030780

About this StructureAbout this Structure

2a4l is a 1 chain structure of Cell Division Protein Kinase 2 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1][xtra 2][xtra 3]

  1. ↑ De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem. 1997 Jan 15;243(1-2):518-26. PMID:9030780
  2. ↑ De Azevedo WF Jr, Mueller-Dieckmann HJ, Schulze-Gahmen U, Worland PJ, Sausville E, Kim SH. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40. PMID:8610110
  3. ↑ De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH. Crystal structure of cyclin-dependent kinase 2. Nature. 1993 Jun 17;363(6430):595-602. PMID:8510751 doi:http://dx.doi.org/10.1038/363595a0

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