3jsd
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitusInsulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Template:ABSTRACT PUBMED 2905485
About this StructureAbout this Structure
3jsd is a 4 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
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- ↑ Baker EN, Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DM, Hubbard RE, Isaacs NW, Reynolds CD, et al.. The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philos Trans R Soc Lond B Biol Sci. 1988 Jul 6;319(1195):369-456. PMID:2905485
- ↑ Bentley G, Dodson E, Dodson G, Hodgkin D, Mercola D. Structure of insulin in 4-zinc insulin. Nature. 1976 May 13;261(5556):166-8. PMID:1272390
- ↑ Derewenda U, Derewenda Z, Dodson EJ, Dodson GG, Reynolds CD, Smith GD, Sparks C, Swenson D. Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer. Nature. 1989 Apr 13;338(6216):594-6. PMID:2648161 doi:http://dx.doi.org/10.1038/338594a0
- ↑ Hua QX, Nakagawa S, Hu SQ, Jia W, Wang S, Weiss MA. Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain. J Biol Chem. 2006 Aug 25;281(34):24900-9. Epub 2006 Jun 8. PMID:16762918 doi:http://dx.doi.org/10.1074/jbc.M602691200
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OCACategories:
- Pages with broken file links
- Arvan, P.
- Brange, J.
- Dodson, E J.
- Dodson, G G.
- Hu, S Q.
- Hua, Q X.
- Huang, K.
- Jia, W H.
- Katsoyannis, P G.
- Liu, M.
- Nakagawa, S H.
- Turkenburg, M.
- Wan, Z L.
- Wang, S H.
- Weiss, M A.
- Whittaker, J.
- Whittingham, J.
- Xu, B.
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Disulfide bond
- Glucose metabolism
- Hormone
- Insulin hexamer
- Insulin's biosynthesis
- Proinsulin
- Secreted