3f8j
Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)
About this StructureAbout this Structure
3f8j is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hashimoto H, Horton JR, Zhang X, Cheng X. UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics. 2009 Jan 10;4(1). PMID:19077538
- ↑ Hashimoto H, Horton JR, Zhang X, Bostick M, Jacobsen SE, Cheng X. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature. 2008 Oct 9;455(7214):826-9. Epub 2008 Sep 3. PMID:18772888 doi:10.1038/nature07280