1w37
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2-KETO-3-DEOXYGLUCONATE(KDG) ALDOLASE OF SULFOLOBUS SOLFATARICUS
OverviewOverview
The hyperthermophilic Archaea Sulfolobus solfataricus grows optimally, above 80 degrees C and metabolizes glucose by a non-phosphorylative, variant of the Entner-Doudoroff pathway. In this pathway glucose, dehydrogenase and gluconate dehydratase catalyze the oxidation of glucose, to gluconate and the subsequent dehydration of gluconate to, D-2-keto-3-deoxygluconate (KDG). KDG aldolase (KDGA) then catalyzes the, cleavage of KDG to D-glyceraldehyde and pyruvate. It has recently been, shown that all the enzymes of this pathway exhibit a catalytic promiscuity, that also enables them to be used for the metabolism of galactose. This, phenomenon, known as metabolic pathway promiscuity, depends crucially on, the ability of KDGA to cleave KDG and D-2-keto-3-deoxygalactonate (KDGal), in both cases ... [(full description)]
About this StructureAbout this Structure
1W37 is a [Single protein] structure of sequence from [Sulfolobus solfataricus] with NA and GOL as [ligands]. Active as [2-dehydro-3-deoxyglucarate aldolase], with EC number [4.1.2.20]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus., Theodossis A, Walden H, Westwick EJ, Connaris H, Lamble HJ, Hough DW, Danson MJ, Taylor GL, J Biol Chem. 2004 Oct 15;279(42):43886-92. Epub 2004 Jul 20. PMID:15265860
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