Colicin E4

Colicin E4 is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its 16s rRNase activity; it digests the 16s ribosomal subunit, ultimately leading to the death of the cell.

Synthesis and releaseSynthesis and release

The colicin E4 operon is encoded on a plasmid in E. coli, alongside a regulatory protein, and its Colicin Immunity Protein, Im4.