Neuroligin

Crystal Structure of human Neuroligin 3be8

Neuroligins (NLGN) are a family of postsynaptic proteins which bind to the presynaptic Neurexin (NRXN) to form a complex which attaches neurons. The NLGN family contains 4 members which are numbered 1 to 4. The images at the left and at the right correspond to one representative NLGN, i.e. the crystal structure of human Neuroligin (3be8).

For Structural Analysis of Neuroligin, See: Neuroligin-Neurexin Interaction

3D Structures of Neuroligin3D Structures of Neuroligin

NLGNNLGN

3bl8 - mNLGN-2 cholinesterase domain – mouse
3be8 - hNLGN-4 cholinesterase domain – human
3bix - rNLGN-1 cholinesterase domain - rat

NLGN+NRXNNLGN+NRXN

2xb6, 2wqz – hNLGN-4 cholinesterase domain+NRXN-1β LNS domain
3b3q - mNLGN-4 cholinesterase domain+NRXN-1β LNS domain
3biw - rNLGN-1 cholinesterase domain+NRXN-1β LNS domain

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Alexander Berchansky, Jaime Prilusky, David Canner, Michal Harel, Pascale Marchot, Joel L. Sussman