Colicin Ia
Colicin Ia is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them by forming a pore in the membrane, leading to depolarisation of the membrane which kills the cell.
Synthesis and releaseSynthesis and release
Mechanism of uptakeMechanism of uptake
Template:STRUCTURE 2hdi The N terminus is responsible for the translocation of colicin Ia across the membrane of the targeted cell. There is much flexibility on this region[1]. The structure shows the receptor binding domain of ColIa bound to its outer membrane receptor, Cir.
ColIa has been shown to transport cargo proteins on its N terminus across the lipid bilayer when it penetrates the target cell. This transport uses the voltage across the bilayer to bring the folded proteins across the membrane[2].