2iwr

File:2iwr.gif

spinqualitylabelsall models 2iwr, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)

OverviewOverview

Centaurins are a family of proteins that contain GTPase-activating protein, domains, with the gamma family members containing in addition a, GTPase-like domain. Centaurins reside mainly in the nucleus and are known, to activate phosphoinositide 3-kinase, a key regulator of cell, proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding, studies, we show that, for CENTG1 (centaurin gamma-1) the GTPase-like, domain has broader trinucleotide specificity. Alterations within the G4, motif of CENTG1 from the highly conserved NKXD found in typical GTPases to, TQDR result in the loss of specificity, a lower affinity for the, nucleotides and higher turnover rates. These results indicate that the, centaurins could be more accurately classified as NTPases and point to, alternative mechanisms of cell signalling control.

About this StructureAbout this Structure

2IWR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The centaurin gamma-1 GTPase-like domain functions as an NTPase., Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA, Biochem J. 2007 Feb 1;401(3):679-88. PMID:17037982

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