Fasciculin

File:1fas.png

Crystal Structure of Fasciculin 1fas

Fasciculins (FASs) are toxins produced by the snake green mamba. FASI and FASII are known to bind to acetylcholinesterase (AChE) and cause severe fasciculations. The images at the left and at the right correspond to one representative FAS, i.e. the crystal structure of Fasciculin 1 (1fas).

3D Structures of Fasciculin3D Structures of Fasciculin

FasciculinFasciculin

1fas – FASI
1fsc - FASII

FAS+ AChEFAS+ AChE

2x8b, 1b41 – FASII+hAChE – human
1f8u - FASII+hAChE (mutant)
1ku6, 1mah - FASII+mAChE – mouse
1fss - FASII+AChE – Torpedo californica