Tubulin

Revision as of 15:03, 16 December 2010 by Alexander Berchansky (talk | contribs) (New page: left|200px|thumb|Crystal Structure of Tubulin [[1z5w]] {{STRUCTURE_1z5w| PDB=1z5w | SIZE=300| SCENE= |right|CAPTION=Tubulin 1z5w }} Tubulin (TUB) is a constit...)
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Template:STRUCTURE 1z5w

File:1z5w.png
Crystal Structure of Tubulin 1z5w

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of alpha-tubulin (TUBA) and beta-tubulin (TUBB) bound to GTP. Gamma-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, i.e. the crystal structure of Tubulin (1z5w).

3D Structures of Tubulin3D Structures of Tubulin

TubulinTubulin

3hkb, 3hkc, 3hkd, 3hke – TUBA+TUBB+stathmin-like protein B3 – sheep
2wbe – cTUBA1D+cTUBB2B+kinesin+AMPPNP – cow
3dco - cTUBA+cTUBB+kinesin-like NOD
1tvk - cTUBA+cTUBB+GDP+GTP+Epothilone A – electron crystallography
3edl - cTUBA1D+cTUBB2B+kinesin motor domain
3du7, 3e22, 1z2b, 1sa0, 1sa1 – cTUBA1C+cTUBB2B+stathmin-like protein B3
1ffx - cTUBA+cTUBB+stathmin-like protein B3
1jff - cTUBA+cTUBB
2p4n - hTUBA+hTUBB+kinesin heavy chain
3cb2 – hTUBG1+GDP
1z5v - hTUBG1+GTPgS
1z5w - hTUBG1+GTP
2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig
2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
1tub - pTUBA+pTUBB – electron diffraction
2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii
2btq – PdTUBA+PdTUBB


FtsZFtsZ

2rhh, 2rhj – BsFtsZ+SO4 – Bacillus subtilis 2rhl - BsFtsZ+GDP 2rho - BsFtsZ+GDP+GTP-gamma-S 2vxy, 2vam – BsFtsZ 2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa 2ve9 - PaFtsZ gamma domain+DNA 2vaw – PaFtsZ+GDP 1ofu - PaFtsZ+SULA 2r75 - AaFtsZ+8-morpholino-GTP – Aquifex aeolicus 2r6r - AaFtsZ 2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis 2q1y, 1rlu - MtFtsZ+GTP-gamma-S 1rq7 - MtFtsZ+GDP 2vap – MjFtsZ+GDP – Methancaldococcus jannaschii 1w58 - MjFtsZ+GMPCPP 1w59, 1fsz – MjFtsZ 1w5a - MjFtsZ+MgGTP 1w5b - MjFtsZ+GTP 1w5e, 1w5f – MjFtsZ (mutant)

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Alexander Berchansky, Michal Harel, Joel L. Sussman