Fibronectin
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).
3D Structures of Fibronectin3D Structures of Fibronectin
Fn module FnIFn module FnI
3m7p – hFn GBD – human 1e8b, 1e88, 1qo6 - hFn GBD – NMR 3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1 1fbr - hFn 4-5FnI 2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide 2rkz, 3cal - hFn 2-3FnI+Fn binding peptide 2cg6, 2cg7 - hFn 2-3FnI 2cku - hFn 2-3FnI – NMR 1o9a - hFn 1-2FnI+B3 from FNBB – NMR 2ec3 – hFn 11FnI – NMR 1qgb – hFn FnI N-terminal - NMR 2ck2 – hFn (mutant) core swapped 1j8k – hFn extra domain 2 – NMR 1fnh – hFn heparin and integrin binding domains
Fn module FnIIFn module FnII
2fn2 – hFn 2FnII – NMR
Fn module FnIIIFn module FnIII
2h41, 2h45 – hFn 2FnIII – NMR 1oww - hFn 1FnIII – NMR 2ha1 - hFn 1-2FnIII – NMR 2crm - hFn 4FnIII – NMR 2crz - hFn 5FnIII – NMR 1fna, 1ttf, 1ttg – hFn 10FnIII 1fnf – hFn 7-10FnIII 2fnb – hFn FnIII ed-b domain – NMR 1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR