2ptu
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Structure of NK cell receptor 2B4 (CD244)
OverviewOverview
Natural killer (NK) cells eliminate virally infected and tumor cells., Among the receptors regulating NK cell function is 2B4 (CD244), a member, of the signaling lymphocyte-activation molecule (SLAM) family that binds, CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose, other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We, determined the structure of the complex between the N-terminal domains of, mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The, complex displayed an association mode related to, yet distinct from, that, of the NTB-A dimer. Binding was accompanied by the rigidification of, flexible 2B4 regions containing most of the polymorphic residues across, different species and receptor isoforms. We propose a model for 2B4-CD48, interactions that permits the intermixing of SLAM receptors with major, histocompatibility complex-specific receptors in the NK cell immune, synapse. This analysis revealed the basis for heterophilic recognition, within the SLAM family.
About this StructureAbout this Structure
2PTU is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family., Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA, Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:17950006
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