ATPase
ATPase catalyzes the breakdown of ATP to ADP and phosphate. This reaction releases energy which is used by the cell in processes like moving solutes through molecular pumps against a gradient. NBD is the nucleotide binding domain. MBD is the metal binding domain. The images at the left and at the right correspond to one representative ATPase, i.e. the NMR structure of rat ATPase (1mo8).
3D Structures of ATPase3D Structures of ATPase
Cu transporting ATPase
2kmv, 2kmx, 2arf – hATPase NBD – human – NMR 2kij - hATPase MBD – NMR 1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR 1y3j, 1y3k - hATPase 5th soluble domain – NMR 1s6o, 1s6u - hATPase 2nd soluble domain – NMR 1q8l - hATPase 2nd MBD – NMR 1aw0, 2aw0 - hATPase 4th MBD – NMR 1kvi, 1kvj - hATPase 1st MBD – NMR 3dxs - AtATPase MBD– Arabidopsis thaliana 3voy - AfATPase – Archaeoglobus fulgidus – CryoEM 2k1r - hATPase MBD+ ATOX1 – NMR 2rop, 2g9o, 2ga7 - hATPase MBD – NMR 2rml - BsATPase N-terminal – Bacillus subtilis – NMR 2gcf - sATPase N-terminal - Synechocystis – NMR 2iye - ATPase catalytic fragment – Sulfolobus solfataricus 1fvq, 1fvs - hATPase – NMR
Na/K transporting ATPase
3a3y - SaATPase+K+ouabain – Squalus acanthias 3b8e - pATPase a+BeF3 - pig 2hc8 –AfATPase CopA A domain 2b8e - AfATPase CopA NBD 2xze - SaATPase 3kdp, 3b8e – pATPase – pig 1mo8, 1mo7 - ATPase alpha-1 – rat 1q3i - pATPase NBD
Ca transporting ATPase
3fgo - rATPase+CPA+AMPPCP – rabbit 3b9r, 1xp5 - rATPase+AlF4 1wpg - rATPase+MgF4 2zbe – rATPase+BeF3 2zbf - rATPase+BeF3+TG 2zbg - rATPase+AlF4+TG 2zbd - rATPase+AlF4+ADP+Ca 2dqs - rATPase+AMPPCP 2c88, 2c8k - rATPase+AMPPCP+TG 1vfp - rATPase+AMPPCP 2ear, 2c8l - rATPase+TG 1iwo - rATPase 2agv - rATPase+TG+BHQ 2eas - rATPase+CPA 2eat - rATPase+CPA+GT 2eau - rATPase+CPA+curcumin 3ba6 - rATPase phosphoenzyme intermediate 3fpb - rATPase+ATP+cyclopiazonic acid 3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid 2o9j - rATPase+MgF4+cyclopiazonic acid 1kju - rATPase E2 state 2c9m - rATPase Ca2E1 state 1t5s - rATPase Ca2E1 state+AMPPCP 1t5t - rATPase Ca2E1 state+ADP+AlF4 1su4 - rATPase +2Ca2 2by4 - rATPase HNE2 state+thapsigargin derivative
Zn transporting ATPase
2ofg, 2ofh - sATPase N-terminal – NMR
K+ transporting ATPase
2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR 1svj, 1u7q - EcATPase NBD of KdpB – NMR
As transporting ATPase
1ii0, 1f48 - EcATPase 1ihu – EcATPase+Mg+ADP+AlF3 1ii9 - EcATPase+AMPPNP
H+ transporting ATPase
3b8c - AtATPase C terminal truncated 1mhs - ATPase – Neurospora crassa
Na+ transporting ATPase
2db4 - ATPase subunit K – Enterococcus hirae 1yce - ATPase rotor ring – Ilyobacter tartaricus
H/K transporting ATPase
1iwc, 1iwf - pATPase NBD 3ixz - pATPase a+AlF4
Mg transporting ATPase
3gwi – EcATPase P-1 NBD
Arg/ornithine transporting ATPase
3md0 – MtATPase+GDP – Mycobacterium tuberculosis
1kmh - ATPase alpha subunit+tentoxin – spinach 1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow 1h8h - cATPase+ AMPPNP 1efr - cATPase+efrapeptin 3fks – ATPase – yeast 3ea0 – ATPase ParA, fragment – Chlorobium tepidum 2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi 3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse 3cf2 - mATPase NBD+ADP+AMP-PNP 2r31, 2p4x – PdATPase ATP12 – Paracoccus denitrificans 2zd2 – PdATPase (mutant) ATP12 1d8s – EcATPase F1 1vdz – ATPase subunit A – Pyrococcus horikoshii