2v0e

OverviewOverview

CHD7 is a member of the chromodomain helicase DNA binding domain (CHD), family of ATP-dependent chromatin remodelling enzymes. It is mutated in, CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a, subset of CHD proteins, unique to metazoans that contain the BRK domain, a, protein module also found in the Brahma/BRG1 family of helicases. We, describe here the NMR solution structure of the two BRK domains of CHD7., Each domain has a compact betabetaalphabeta fold. The second domain has a, C-terminal extension consisting of two additional helices. The structure, differs from those of other domains present in chromatin-associated, proteins.

About this StructureAbout this Structure

2V0E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Solution Structure of the BRK Domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Jun 9;. PMID:17603073

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