Bungarotoxin

Crystal Structure of α-Bungarotoxin 2abx

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait. α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. β-BGT binds to the presynaptic terminal causing release of acetylcholine. The images at the left and at the right correspond to one representative Bungarotoxin , i.e. the crystal structure of α-Bungarotoxin (2abx).

3D Structures of Bungarotoxin3D Structures of Bungarotoxin

BungarotoxinBungarotoxin

2abx – α-BGT
1kfh, 1ik8, 1ikc, 1idi, 1idl, 2nbt – α-BGT - NMR
1mr6 – γ-BGT – NMR
1kba – κ-BGT

BGT+binding peptideBGT+binding peptide

1rji, 1l4w, 1ljz, 1kc4, 1kl8, 1jbd, 1haa, 1haj, 1idg, 1idh, 1hoy, 1bxp, 1btx, 1abt, 1rgj – α-BGT+AChR peptide - NMR
1hc9 α-BGT+AChR peptide

BGT+ AChR subunitBGT+ AChR subunit

2qc1 – α-BGT+mAChR a subunit

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Alexander Berchansky, Jaime Prilusky, Michal Harel