Alzheimer's Disease

Alzheimer's Disease, is the most common form of dementia, especially in individuals over 65 years old. It is predicted to affect 1 in 85 people by 2050.

Comparison of Normal Brain (Left) & Brain with Alzheimer's (Right)

Articles in Proteopedia concerning Alzheimer's Disease include:

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• Acetylcholine
• Acetylcholinesterase
• Acetylcholinesterase from Torpedo Californica
• African Malaria Mosquito Acetylcholinesterase
• Beta-Secratase
• Human APP Intracellular Domain Complex with Fe65-PTB2
• Aromatic Residue Flexibility in AChE
• Beta Amyloid
• Acetylcholine binding protein (AChBP)
• Butyrylcholinesterase (BChE)
• Drug Compounds & Substrates
  • Bivalent Inhibitors of Acetylcholinesterase
  • Bivalent Inhibitors of Acetylcholinesterase, Part II
  • Inhibitors and Substrates of Acetylcholinesterase
  • Inhibitors and Substrates of Acetylcholinesterase, Part II
  • Inhibitors and Substrates of Acetylcholinesterase, Part III
  • Specific Examples:
    • Aricept Complexed with Acetylcholinesterase
    • DFP (Aged) Complexed with Acetylcholinesterase
    • Edrophonium Complexed with Acetylcholinesterase or Here
    • Fluorophore Thioflavin T Complexed with Acetylcholinesterase
    • Galanthamine Complexed with Acetylcholinesterase
    • Huperzine A Complexed with Acetylcholinesterase
    • Iminium Galanthamine Derivative bound to Acetylcholinesterase or Here, or Here.
    • NAP Complexed with Acetylcholinesterase
    • O-tthylmethylphosphonylated Acetylcholinesterase
    • Soman Complexed with Acetylcholinesterase or Here, or Here, or Here, or Here.
    • Tacrine Complexed with Acetylcholinesterase
  • Bivalent Inhibitors
    • Anticancer Prodrug CPT-11 Complexed with Acetylcholinesterase
    • Aricept Complexed with Acetylcholinesterase
    • Bis-Acting Galanthamine Derivative Complexed with Acetylcholinesterase, or Here, or Here
    • Bis-Tacrine Derivative Complexed with Acetylcholinesterase or Here or Here
    • Bisquaternary Decamethonium Complexed with Acetylcholinesterase
    • BW284C51 Complexed with Acetylcholinesterase
    • Hupyridone Derivative Complexed with Acetylcholinesterase, or Here, or Here, or Here
    • N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE Complexed with Acetylcholinesterase
    • PEG-SH Complexed with Acetylcholinesterase
• Gamma-Secratase
• Monamine Oxidase B
• Glutamate Receptor
  • Glutamate receptor (GluA2)
  • Glutamate Receptor for Molecular Playground display
• Human APP

To view automatically seeded indices concerning Alzheimer's Disease See:

• Acetylcholinesterase
• Alzheimer's Disease
• Amyloid

To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets