Cadherin

Crystal Structure of Cadherin, 1q1p

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, i.e. the crystal structure of Cadherin (1q1p). Calcium ions is shown as a space filling objects.

3D Structures of Cadherin3D Structures of Cadherin

CDH encoded by CDH1CDH encoded by CDH1

1q1p – mCDH1 - mouse

CDH encoded by CDH5CDH encoded by CDH5

2koh – mCDH5+PAR3-PDZ3

CDH encoded by CDH6CDH encoded by CDH6

3lnd – mCDH6 EC12 (mutant)

CDH encoded by CDH8CDH encoded by CDH8

1zxk – mCDH8 EC1
2a62 - mCDH8 EC1+EC2+EC3

CDH encoded by CDH11CDH encoded by CDH11

2a4c, 2a4e – mCDH11 EC1

CDH encoded by CDH20CDH encoded by CDH20

1zvn – cCDH20 EC1 – chicken

CDH encoded by CDH23CDH encoded by CDH23

3mvs, 2whv – mCDH23 N-terminal
2kbr – hCDH23 peptide+harmonin – NMR - human
2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR

C-CDH “classical”C-CDH “classical”

1l3w – XlC-CDH ectodomain - Xenopus laevis
1q5b, 1q5c – C-CDH model into desmosome – electron tomography

E-CDH epithelialE-CDH epithelial

1ff5 – mE-CDH double domain
1edh - mE-CDH EC1+EC2+Ca
1suh – mE-CDH N-terminal - NMR
3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin
3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)
3ifq – hE-CDH EC1+EC2+EC3
2o72 - hE-CDH EC1+EC2
3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor
2qvf – mE-CDH1 CDH2
2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes

T-CDH membrane boundT-CDH membrane bound

3k5r – mT-CDH EC1+EC2
3k5s - cT-CDH EC1+EC2
3k6d - XlT-CDH EC1
3k6f - mT-CDH EC1
3k6i - cT-CDH EC1
2v37 – hT-CDH N-terminal - NMR

N-CDH neuronalN-CDH neuronal

1nch, 1nci – mN-CDH
1ncg – mN-CDH (mutant)
2qvi – mN-CDH EC12
1ncj – mN-CDH two domains

ProtocadherinProtocadherin

2yst – hProt-CDH7 EC3 – NMR

DesmogleinDesmoglein

2yqg – hDes-CDH EC1

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel