Telomerase 3D structures

Structure of the catalytic subunit of telomerase, TERT, 3du5

Telomerase (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 Telomerase Reverse Transcriptase (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, i.e. crystal structure of catalytic subunit of telomerase, TERT, from Tribolium castaneum (3du5).

3D Structures of Telomerase3D Structures of Telomerase

3kyl, 3du5, 3du6 – TERT+DNA – Tribolium castaneum
2r4g – TtTERT RNA binding domain+RNA – Tetrahymena thermophila
2b2a – TtTERT (mutant)

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Alexander Berchansky, Michal Harel, Jaime Prilusky