Tropomyosin
3D Structure of Tropomyosin
The image at the top is a Tropomyosin from Sus scrofa (1c1g)
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| Tropomyosin from Sus scrofa, 1c1g | |||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
TropomyosinTropomyosin
Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca+ atoms bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin.
3D Structure of Tropomyosin3D Structure of Tropomyosin
3mtu, 3mud – cTPM alpha-1 – chicken
1ic2 - cTPM alpha-1 (mutant)
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 – rabbit
1kql - TPM alpha-1 C-terminal+GNC4 - rat
2b9c – TPM mid region – rat
1c1g – TPM – pig
2tma – TPM - model