2bpi
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STUCTURE OF IRON DEPENDENT SUPEROXIDE DISMUTASE FROM P. FALCIPARUM.
OverviewOverview
BACKGROUND: Superoxide dismutases (SODs) are important enzymes in defence, against oxidative stress. In Plasmodium falciparum, they may be expected, to have special significance since part of the parasite life cycle is, spent in red blood cells where the formation of reactive oxygen species is, likely to be promoted by the products of haemoglobin breakdown. Thus, inhibitors of P. falciparum SODs have potential as anti-malarial, compounds. As a step towards their development we have determined the, crystal structure of the parasite's cytosolic iron superoxide dismutase., RESULTS: The cytosolic iron superoxide dismutase from P. falciparum, (PfFeSOD) has been overexpressed in E. coli in a catalytically active, form. Its crystal structure has been solved by molecular replacement and, refined ... [(full description)]
About this StructureAbout this Structure
2BPI is a [Single protein] structure of sequence from [Plasmodium falciparum] with FE as [ligand]. Active as [Superoxide dismutase], with EC number [1.15.1.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The crystal structure of superoxide dismutase from Plasmodium falciparum., Boucher IW, Brzozowski AM, Brannigan JA, Schnick C, Smith DJ, Kyes SA, Wilkinson AJ, BMC Struct Biol. 2006 Oct 4;6:20. PMID:17020617
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