1hav
HEPATITIS A VIRUS 3C PROTEINASE
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OverviewOverview
The virally encoded 3C proteinases of picornaviruses process the, polyprotein produced by the translation of polycistronic viral mRNA. The, X-ray crystallographic structure of a catalytically active mutant of the, hepatitis A virus (HAV) 3C proteinase (C24S) has been determined. Crystals, of this mutant of HAV 3C are triclinic with unit cell dimensions a = 53.6, A, b = 53.5 A, c = 53.2 A, alpha = 99.1 degrees, beta = 129.0 degrees, and, gamma = 103.3 degrees. There are two molecules of HAV 3C in the unit cell, of this crystal form. The structure has been refined to an R factor of, 0.211 (Rfree = 0.265) at 2.0-A resolution. Both molecules fold into the, characteristic two-domain structure of the chymotrypsin-like serine, proteinases. The active-site and substrate-binding regions are ... [(full description)]
About this StructureAbout this Structure
1HAV is a [Protein complex] structure of sequences from [Hepatitis a virus] with CL as [ligand]. Active as [RNA-directed RNA polymerase], with EC number [2.7.7.48]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [OCA].
ReferenceReference
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition., Bergmann EM, Mosimann SC, Chernaia MM, Malcolm BA, James MN, J Virol. 1997 Mar;71(3):2436-48. PMID:9032381
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