Molecular Playground/ERMan1
This is a placeholderThis is a placeholder
Alpha-mannosidases I(ERMan1) is a human protein that reside in the endoplasmic reticulum(ER). ERMan1 is part of the class 1 glycosylhydrolase family 47 group of proteins and sports a Tim-barrel fold. Asparagine(N)-linked glycans are common covalent modifiers in the ER that aid in protein folding and trafficking. ERMan1 trims N-linked glycans to make the client protein targeted for degradation. The slow acting kinetics of ERMan1 has been proposed to give at hand a defined window of time before the client protein can be targeted for degradation by other ER proteins.
| |||||||||
| 1x9d, resolution 1.41Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||||
| Gene: | MAN1B1 (Homo sapiens) | ||||||||
| Activity: | Mannosyl-oligosaccharide 1,2-alpha-mannosidase, with EC number 3.2.1.113 | ||||||||
| Related: | 1fmi | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
"Molecular Playground banner: A catalytic timer for protein degradation."