3lpb

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Template:STRUCTURE 3lpb

File:3lpb.jpg

Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitorCrystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor

Template:ABSTRACT PUBMED 20231096

About this StructureAbout this Structure

3LPB is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Pissot-Soldermann C, Gerspacher M, Furet P, Gaul C, Holzer P, McCarthy C, Radimerski T, Regnier CH, Baffert F, Drueckes P, Tavares GA, Vangrevelinghe E, Blasco F, Ottaviani G, Ossola F, Scesa J, Reetz J. Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2609-13. Epub 2010 Feb 19. PMID:20231096 doi:10.1016/j.bmcl.2010.02.056

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OCA

[1] Pissot-Soldermann C, Gerspacher M, Furet P, Gaul C, Holzer P, McCarthy C, Radimerski T, Regnier CH, Baffert F, Drueckes P, Tavares GA, Vangrevelinghe E, Blasco F, Ottaviani G, Ossola F, Scesa J, Reetz J. Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2609-13. Epub 2010 Feb 19. PMID:20231096 doi:10.1016/j.bmcl.2010.02.056

[xtra 1]