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ER Man 1

ER Mannosidase 1 is a type II ER membrane protein that. EMechanism of class 1 (glycosylhydrolase family 47) Alpha-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control.

Alpha-mannosidases I is a human protein that reside in the endoplasmic reticulum(ER) lumen. ERMan1 is part of the class 1 glycosylhydrolase family 47, group of proteins and sports a Tim-barrel fold. In the ER N-linked glycans are used as a indicator of how wella client protein is folded. ERMan1 functions by slowly trimming N-linked glycans, giving the protein at hand a defined window of time before the client protein will be detected as misfolded by other ER proteins.


ERMan1 (1X9D)

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Catalytic SiteCatalytic Site

The spinning protein () ) is a highlight of the catalytic residues of ERMan1.


Molecular Playground banner: A catalytic timer for protein degradation.

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