1h07
CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR
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OverviewOverview
Using a high-throughput screening campaign, we identified the 4,6-bis, anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4., Herein we describe the further chemical modification and use of X-ray, crystallography to develop potent and selective in vitro inhibitors of, CDK4.
About this StructureAbout this Structure
1H07 is a Single protein structure of sequence from Homo sapiens with ACE and MFP as ligands. Active as Transferred entry: 2.7.11.1, with EC number 2.7.1.37 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines., Beattie JF, Breault GA, Ellston RP, Green S, Jewsbury PJ, Midgley CJ, Naven RT, Minshull CA, Pauptit RA, Tucker JA, Pease JE, Bioorg Med Chem Lett. 2003 Sep 15;13(18):2955-60. PMID:12941311
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