Interleukin-10
Interlukin-10 2H24Interlukin-10 2H24
Crystal structure of human IL-10Crystal structure of human IL-10
This is a cytokine.[1] Cytokines function as....[2] Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA).(Katsikis et al.) RA is an autoimmune disorder that affects the synovial tissues of the affected persons, via chronic synovitis. The chronic synovitis often results in joint destruction due to re-absorption of bone and (Katsikis et al and Nemec et al)
IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue.
The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual. (Nemec) Make a link to the wiki website that talks about cytokines. Make a link to RA
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Shelly Huebert
ReferencesReferences
- ↑ Yoon SI, Logsdon NJ, Sheikh F, Donnelly RP, Walter MR. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem. 2006 Nov 17;281(46):35088-96. Epub 2006 Sep 18. PMID:16982608 doi:10.1074/jbc.M606791200
- ↑ Reference 2
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[1] Ref1
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