Triose Phosphate Isomerase Structure & Mechanism

Triose Phosphate Isomerase (TIM)Triose Phosphate Isomerase (TIM)

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Triose phosphate isomerase (TIM) is a crucial enzyme in the glycolytic pathway. TIM reversibly converts the aldose Glyceraldehyde-3-phosphate (GASP) to the ketose Dihydroxyacetone phosphate (DHAP). The interconversion proceeds by an enediol intermediate.

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PDB ID 3cin

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3cin, resolution 1.70Å ()
Ligands: , ,
Gene: TM1419, TM_1419 (Thermotoga maritima MSB8)
Activity: Inositol-3-phosphate synthase, with EC number 5.5.1.4
Resources: FirstGlance, OCA, RCSB, PDBsum, TOPSAN
Coordinates: save as pdb, mmCIF, xml


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Christian Krenk, David Canner, Diamond B. Reese, Michal Harel, Jane S. Richardson, Alexander Berchansky