Fructose Bisphosphate Aldolase

Fructose biphosphate aldolase

    Fructose biphosphate aldolase is an enzyme in glycolysis.  It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP).  The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation.  Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33.   aldol cleavage produces GAP and an enamine precursor to DHAP.  Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.

Template:STRUCTURE 2ald

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