2fno
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Crystal structure of Putative glutathione S-transferase (15162326) from AGROBACTERIUM TUMEFACIENS at 2.00 A resolution
OverviewOverview
Glutathione S-transferases (GSTs) comprise a diverse superfamily of, enzymes found in organisms from all kingdoms of life. GSTs are involved in, diverse processes, notably small-molecule biosynthesis or detoxification, and are frequently also used in protein engineering studies or as, biotechnology tools. Here, we report the high-resolution X-ray structure, of Atu5508 from the pathogenic soil bacterium Agrobacterium tumefaciens, (atGST1). Through use of comparative sequence and structural analysis of, the GST superfamily, we identified local sequence and structural, signatures, which allowed us to distinguish between different GST classes., This approach enables GST classification based on structure, without, requiring additional biochemical or immunological data. Consequently, analysis of the atGST1 crystal structure suggests a new GST class, distinct from previously characterized GSTs, which would make it an, attractive target for further biochemical studies.
About this StructureAbout this Structure
2FNO is a Single protein structure of sequence from Agrobacterium tumefaciens str. c58 with SCN as ligand. This structure superseeds the now removed PDB entry 1ZGM. Full crystallographic information is available from OCA.
ReferenceReference
Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution., Kosloff M, Han GW, Krishna SS, Schwarzenbacher R, Fasnacht M, Elsliger MA, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Feuerhelm J, Grittini C, Grzechnik SK, Hale J, Hampton E, Haugen J, Jaroszewski L, Jin KK, Johnson H, Klock HE, Knuth MW, Koesema E, Kreusch A, Kuhn P, Levin I, McMullan D, Miller MD, Morse AT, Moy K, Nigoghossian E, Okach L, Oommachen S, Page R, Paulsen J, Quijano K, Reyes R, Rife CL, Sims E, Spraggon G, Sridhar V, Stevens RC, van den Bedem H, Velasquez J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Proteins. 2006 Nov 15;65(3):527-37. PMID:16988933
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