User:Eric Martz/Sandbox 9

Tamiflu Binds to N1 by Induced FitTamiflu Binds to N1 by Induced Fit

spinqualitylabelsall models Morph of N1 alone (2hty) to N1 complexed with Tamiflu (2hu4). The position where Tamiflu will bind is shown translucent except when bound in the empirically-determined model. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Tamiflu was designed to fit N2/N9, so it is serendipitous that it works on N1. In fact, when the structure of N1 was determined, the loop comprising residues 147-152 was not in a suitable position to participate in binding Tamiflu. However, the complex of N1 with Tamiflu revealed that this loop is pulled into proper contact with the drug in an induced fit manner. A morph from N1 alone (2hty) to N1 complexed with Tamiflu (2hu4) shows the change in position of this loop ().

The binding of Tamiflu to N1 pulls the sidechains of two conserved residues, , closer to the inhibitor.